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Aspirin blocks the production of thromboxane A-2, a chemical secreted by platelets that helps the platelets to clump.

The patients randomized had: 1) recent histories of myocardial infarction (within 35 days); 2) recent histories of ischemic stroke (within 6 months) with at least a week of residual neurological signs; or 3) established peripheral arterial disease.

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Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record.

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The footnote to Table 2 states that death from cardiovascular causes and death from fatal hemorrhage were not mutually exclusive, with intracranial hemorrhage and death after cardiovascular procedures that were complicated by fatal bleeding included in both end points, which therefore cannot be summed without double-counting.

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Effect of early, pre-hospital initiation of high bolus dose tirofiban in patients with ST-segment elevation myocardial infarction on short- and long-term clinical outcome.

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Other risk factors that were shown to be associated with an increased risk for stroke and are included in the tool are age, sex, diabetes, smoking, known cardiovascular disease, atrial fibrillation, and left ventricular hypertrophy ().

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If a number of alternative treatment options are recommended, offering patients choices encourages active participation in their treatment.

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Because PPIs are metabolized by the same hepatic isoenzyme (), concern has been raised that PPIs might inhibit the conversion of clopidogrel to its active metabolite and thereby diminish its clinical benefit.

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